Jake Rudock threw a pair of touchdown passes and ran for another score, Mark Weisman added 145 yards rushing and Iowa hung on to beat rival Iowa State 27-21 on Saturday night.
Kevonte Martin Manley had seven catches and a TD for the Hawkeyes (2-1).
Iowa ran the ball 60 times for 218 yards and snapped a two-game losing streak against the Cyclones.
Quenton Bundrage rallied the Cyclones with two touchdown receptions with less than five minutes left.
But Iowa recovered an onside kick and snuffed out a last-gasp try by Iowa State.
Bundrage had a career-high 146 yards receiving and three TD grabs for Iowa State, which is 0-2 for the first time since 2007.
Sam Richardson had 258 yards passing for the Cyclones.