Jarrod Uthoff scored a season-high 19 points as Iowa beat Penn 86-55 on Friday night.
Devyn Marble added 13 points and a career-high five steals for the Hawkeyes (5-0).
Darien Nelson-Henry scored 13 points to lead Penn (1-3).
Iowa forced a season-high 25 turnovers - 17 in the first half.
The Hawkeyes finished with 14 steals and 30 points off turnovers.
Uthoff shot 6 of 7 from the field and made all six of his free throws. Uthoff's fully extended dunk over a Penn defender drew the biggest reaction from Hawkeye fans.
Iowa made 28 of 40 free throws. Penn only attempted 16 foul shots.
Nine Hawkeyes scored at least five points. Mike Gesell scored 10 points. Gabe Olaseni added eight points, six rebounds and three blocks.
Iowa coach Fran McCaffery graduated from Penn. He played three seasons with the Quakers from 1979-82.