Jabari Brown scored 22 points and Jordan Clarkson added 21 to help Missouri upset No. 18 UCLA 80-71 on Saturday.
Two free throws by Johnathan Williams III gave Missouri (9-0) a 62-60 lead it wouldn't relinquish with 9:30 remaining.
The team trailed for most of the first half and into the second before Earnest Ross made a 3-pointer with 14:46 left.
The win extended Missouri's NCAA-best, home-court winning streak to 24 games and the Tigers' run of 79 consecutive wins against non-conference opponents at Mizzou Arena.
The victory was the first in that stretch against a nationally ranked team.
Jordan Adams scored 22 points and had 10 rebounds for UCLA (8-1), which dropped its first road game this season.
Kyle Anderson and Zach LaVine each added 13 points
The Tigers remain the only unbeaten team in the Southeastern Conference and are off to their best start since the 2006-07 season.
UCLA entered the game averaging a Pac-12 leading 90.6 points.