James Franklin threw for 318 yards and three touchdowns before coming out early in the third quarter, helping Missouri take command after early struggles and whip Murray State 58-14 Saturday night in an opener that began in 98-degree heat.
Henry Josey had 113 yards on 13 carries with a 68-yard score in his first game back from a left knee injury that required two surgeries and sidelined him all last season.
Russell Hansbrough had 104 yards on eight attempts with a pair of scores for Missouri, coming off a disappointing 5-7 record in its first SEC season.
Maikhail Miller threw three interceptions, two by E.J. Gaines, against a defense that stiffened after allowing two early touchdowns.
Murray State faded quickly against its first SEC opponent since 2005.