Henry Josey rushed for two touchdowns, Marcus Murphy added another and No. 8 Missouri rolled to a 24-10 victory over No. 24 Mississippi on Saturday night.
Missouri (10-1, 6-1 Southeastern Conference) is now one victory away from clinching the SEC East title.
The Tigers host Texas A&M next weekend.
Missouri jumped out to a 17-3 lead by halftime and led by a comfortable margin for most of the second half.
James Franklin completed 12 of 19 passes for 142 yards and an interception in his first start since a shoulder injury caused him to miss four games.
Josey rushed for 95 yards.
The loss snapped a four-game winning streak for Ole Miss (7-4, 3-4).
Bo Wallace threw for 244 yards and an interception, but was battling an illness for much of the game and struggled during the second half.