James Franklin made crucial big plays on consecutive scoring drives in the second half and Missouri pulled away from Toledo for a 38-23 victory on Saturday.
Missouri (2-0) led 24-23 after Toledo (0-2) scored its first two touchdowns of the year but Franklin's 21-yard keeper set up Henry Josey's second 1-yard touchdown run of the game which extended Missouri's lead to eight.
The quarterback later had a 6-yard carry on fourth-and-3 and an 11-yard gain on third-and-9 to set up Marcus Murphy's 8-yard run to conclude the scoring with 10:29 to go.
Missouri coach Gary Pinkel beat the school at which he's a Hall of Famer and the career wins leader.
Toledos' David Fluellen had 111 yards on 14 carries and 10 catches for 100 yards.