Jabari Brown scored 15 points while Jordan Clarkson and Earnest Ross both added 12 to help No. 24 Missouri defeat Western Michigan 66-60 on Sunday.
Missouri (10-0) looked rusty at times after an eight-day break for final exams and clung to a 47-45 lead with 10:46 remaining.
Tony Criswell's jumper two minutes later capped a 9-0 run as the Tigers pulled away.
Missouri stretched its NCAA-best homecourt winning streak to 25 games and has won 80 straight games against nonconference opponents at Mizzou Arena dating to the 2005-06 opener.
St. Louis native David Brown led Western Michigan (5-4) with 18 points and Shayne Whittington added 16 points and 10 rebounds.