The Billikens (24-2, 11-0 Atlantic-10), playing as a Top 10 team for the first time since Dec. 29, 1964, extended their school-record winning streak and remained with No. 1 Syracuse and No. 3 Wichita State as the only teams in the country without a loss on the road.
Sherrod Wright had a career-high 34 points for the Patriots (9-17, 2-10), which lost for the 11th time in 13 games and are still without a home win in conference play.
Loe hit consecutive 3-pointers to give the Billikens a 79-77 lead with 3:10 remaining in overtime, and Saint Louis would not relinquish the lead from that point.
The teams played overtime in their earlier meeting, an 87-81 Saint Louis win on Feb. 1.