Backup quarterback Davis Webb threw for three touchdowns and 415 yards in place of the injured Baker Mayfield to lead No. 20 Texas Tech over Iowa State 42-35 on Saturday.
Webb was 35 for 56 with an interception and Kenny Williams, DeAndre Washington and Sadale Foster each ran for a score for Texas Tech (6-0, 3-0 Big 12).
The Red Raiders are bowl eligible at the earliest date since 2008 in their first season under coach Kliff Kingsbury.
The Cyclones (1-4, 0-2) got a 95-yard kickoff return and 38-yard punt return from Jarvis West, and 12 points off three turnovers by the Red Raiders.
The Cyclones pulled within 42-35 on a touchdown pass from Sam Richardson to E. J. Bibbs with less than 2 minutes left. Richardson was 15 for 38 for 168 yards and a touchdown.