Chiefs coach Andy Reid will make his return to Philadelphia when Kansas City visits the Eagles for a Thursday night game in mid-September.
Kansas City opens the season Sept. 8 at Jacksonville, plays its home opener Sept. 15 against Dallas, and then visits the Eagles - where Reid spent 14 years as head coach - on Sept. 19 for a prime-time game.
The Chiefs return home against the Giants on Sept. 29, visit Tennessee the next week, and then have three straight at Arrowhead Stadium against Oakland, Houston and Cleveland.
They visit Buffalo before a bye week Nov. 10, and then visit the Broncos before two more at home against San Diego and Denver.
The Chiefs play three of their last four on the road: at Washington and Oakland, against Indianapolis on Dec. 22, and at San Diego to finish the season.