Rafael Nadal was a first round casualty at Wimbledon.
The men's No. 5, fresh off his win in the French Open, was ousted by Belgium's Steve Darcis the world's 135th ranked player, 7-6, 7-6, 6-4.
The loss was the first for Nadal, a two-time Wimbledon winner, in the first round of a major.
His opening round record in majors is now 34-1. The defeat ended Nadal's 22-match winning streak.
The fifth-seed in the women's division was also a loser on Day 1 as Sara Errani of Italy was beaten in straight sets by Puerto Rican teenager Monica Puig Errani.
In other results, women's second-seed Victoria Azarenka won her opening match in straight sets, as did third-seed Maria Sharapova and No. 12 Ana Ivanovic.
Azarenka overcame a right knee injury when she slipped and fell during the second set.
She was sobbing on the court and received treatment during an injury timeout.
She played the rest of the match with a heavy wrap on her right knee.
Back to the men, defending champion and third-seed Roger Federer opened play with a straight sets win over Romania's Victor Hanescu 6-3, 6-2, 6-0.
The match took just 68 minutes as Federer is looking for his eighth title at the All England Club.
Second-seed Andy Murray, the British favorite every year at Wimbledon, reached the second round with a straight sets win over Germany's Benjamin Becker.
Murray lost to Federer in last year's final.
Sixth-seeded Jo-Wilfried Tsonga of France eased into the second round with a 7-6, 6-4, 6-3 win over David Goffin.
Tsonga reached the semifinals of the grass-court tournament last year.
Men's No. 18 John Isner finished a quick Grand Slam match for a change, beating 66th-ranked Evgeny Donskoy of Russia 6-1, 7-6, 7-6.
The 6-foot-9 Isner, who is seeded 18th, had 22 aces with just one double-fault as the match took only 1 hour, 43 minutes.