Sam Bradford threw three touchdown passes, St. Louis added a score on defense and special teams and the Rams stunned the mistake-prone Houston Texans with a 38-13 win on Sunday.
The Rams (3-3) were up 24-6 early in the third quarter before rookie Daren Bates returned Keshawn Martin's fumble on a kickoff return for a touchdown.
Alec Ogletree pushed the lead to 38-6 when he took an interception by T.J. Yates back 98 yards for a touchdown.
Yates was in after Matt Schaub sustained an apparent right ankle injury.
Schaub didn't have a turnover after throwing six interceptions, three of them returned for touchdowns in the past three games.
But several other Texans had key gaffes as preseason Super Bowl hopeful Houston (2-4) lost its fourth straight game.