Rickie Weeks homered twice and drove in four runs Tuesday night as the Milwaukee Brewers beat the Chicago Cubs 9-3.
Jonathan Lucroy added a two-run double and Juan Francisco also homered for Milwaukee, which has defeated Chicago 19 of the last 21 times at home, including nine in a row.
Kyle Lohse (3-6) gave up eight hits and three earned runs in seven innings.
He struck out three and did not walk a batter.
Chicago's Edwin Jackson (3-10) allowed six earned runs and six hits in 4 2-3 innings to fall to 0-3 against Milwaukee this season.
Cubs shortstop Starlin Castro, mired in a 13-for-98 (.133) slump, had his streak of appearing in 269 consecutive games come to an end. It was the longest active streak in the National League.