Marcus Semien hit a tiebreaking RBI double in a two-run 12th, Jose Quintana pitched one-hit ball over seven innings, and the Chicago White Sox beat the Cubs 3-1 at Wrigley Field on Monday night.
Quintana and five relievers combined on a four-hitter, and the White Sox came away with the win after dropping four straight and six of seven to their crosstown rivals.
The winning rally started when Alexei Ramirez singled off Justin Grimm with two out and stole second.
Tyler Flowers walked, and Semien lined a 1-1 pitch over third baseman Mike Olt's head to make it 2-1.
Grimm (1-1) plunked pinch-hitter Paul Konerko on the left arm to load the bases and walked Alejandro De Aza to make it a two-run game.